Some observational studies show that abnormal sebum lipid composition is associated with worsened disease and that acne patients have low linoleate levels in skin while high levels prevent comedogenesis 3. Its pathogenesis is multifactorial and thought to involve complex and poorly understood lipid-associated pathways. It is a disease of the pilosebaceous unit that is classically associated with hyperkeratinization, increased sebum production, and an inflammatory cytokine response thought to be triggered by the commensal bacterium Propionibacterium acnes (PA) 1, 2. G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human MonocytesĪndrew J Park, 1, 2, * George W Agak, 1, * Min Qin, 1 Lisa D Hisaw, 1 Aslan Pirouz, 1 Stephanie Kao, 1 Laura J Marinelli, 1, 3 Hermes J Garbán, 1 Diane Thiboutot, 4 Philip T Liu, 5, †ġDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ĢGeisel School of Medicine, Dartmouth College, Hanover, NH, USA.ģDepartment of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ĤDepartment of Dermatology, Penn State University College of Medicine, Hershey, PA, USA.ĥDepartment of Orthopedic Surgery, Orthopedic Hospital Research Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.Īcne vulgaris is a common skin disease that affects upwards of 85% of adolescents and frequently persists into adulthood. English.Ĭopyright © 2017 The Korean Dermatological Association and The Korean Society for Investigative Dermatology
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